Endocrine Abstracts

Introduction: Oral levothyroxine (LT4) is the standard treatment for hypothyroidism and serum TSH represents the best marker for assessing the proper LT4 dose. The absorption and bioequivalence of different commercial LT4 preparations might be variable. The aim of this study is to compare the efficacy of levothyroxine oral solution vs tablets.Methods: Fifty-eight patients (six males, 52 females; average age, 46.9±12....

Alzheimer’s disease (AD) is a neurodegenerative diseasethat is manifested by a progressive loss of cognitive and behavioral function. In previous studies, we have constructed a predictive model for the classification of AD patients based on levels of circulating steroids and their polar conjugates.Both AD and Type 2 diabetes mellitus(T2DM) are well known to affect the levels of some steroid hormones, however, in the opposite direction, and in a gen...

Introduction: Differentiated thyroid cancer (DTC) prognosis is usually favorable, even when metastatic radioiodine avid disease is present. Radioiodine-refractory disease, usually a sign of higher aggressiveness, can be detected by 18F-FDG-PET/CT. There is a reverse relationship between iodine and FDG accumulation in thyroid cancer lesions, the so-called ‘‘flip-flop’’ phenomenon: when thyroid cancer cells dedifferentiate they tend to lose the...

Introduction: Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are distinct neoplasms, associated with different histological findings. Their coexistence in the same patient is a rare event, requiring a different clinical approach.Clinical case: A 72-year-old patient with no family history of thyroid disease, underwent total thyroidectomy in February 2019, due to toxic multinodular goitre, with no evidence of postoperative complica...

Background: Sodium-glucose cotransporter-2 (SGLT-2) inhibitors were recently approved as adjunctive treatment for type 1 diabetes (T1D), contributing to better glycemic control, cardiovascular and renal protection. Aim: access the efficacy and safety of these antidiabetic agents in selected T1D patients.Methods: Evaluation of medical records of T1D patients starting SGLT-2 inhibitors between August 2018 and October 2019.Results: 24...

Introduction: Iron deficiency contributes to stabilization of HIF1α and upregulation of genes that stimulate angiogenesis in diseases associated with oxidative stress. The authors’ interest is centered on evaluation of the relation between iron status and angiogenesis (VEGF-A, sVEGFR) in patients with melanoma.Methods: The study included 128 patients with melanoma before surgical removal of the tumor. We determined ferritin (immunoturbidimetric...

Introduction: Di George syndrome is a genetic disorder caused by deletion of chromosome 22. The main features are congenital heart defects, absence or hypoplasia of thymus (with consecutive immunodeficiency and infections), hypoparathyroidism with hypocalcaemia, gastrointestinal problems, delayed psychomotor development, craniofacial abnormalities, tendency to develop seizures and psychiatric disorders.Case report: We present the case of two patients wit...

Sleep apnea syndrome is highly prevalent in acromegaly and only partially reversible after biochemical control of the disease. Consequences of SAS are serious and are associated with increased morbidity and mortality.The present study evaluates clinical aspects in acromegalic patients with sleep apnea syndrome (SAS), diagnosed and followed-up in the Clinic of Endocrinology, Timisoara, in the period 2007–2010. All the cases were confirmed and investi...

Study: Retrospective, cohort.Material and methods: A. Hashimoto thyroiditis (HT) diagnosis: i) antithyroperoxydase antibodies (ATPO) criteria; cut-off >34 IU/ml. ii) If ATPO=normal (N), HT was considered only antithyroglobuline antibodies (ATG) were >50 IU/ml (↑) and ultrasound was pattern 1 (pseudonodular, intense hypoechogenic, inhomogeneous – Peretianu, Endocrine Abstracts, 2007, 14, P340; 2008, 16, P772; 2009, 20, P79).<p class...

Premises: Numerous recent medical journals and communications insist on the high prevalence of Hashimoto’s thyroiditis (HT) associated with breast cancer in women (see www.ncbi.nlm.nih.gov/ key words: breast cancer, thyroiditis, #91).Objective: We proposed to present data from our casuistry related to HT (over 2000 patients and control, including men), observed during last 10 years.Mat...